The Irish whistler, who usually operates in the Airtricity League, will take charge of the game as part of the Football Association of Wales' referee exchange programme with the Scotland, Northern Ireland and the Irish Republic.
It is not the first time that the Saints have been refereed under the exchange scheme - Scotsman Callum Murray took charge of a game against Bangor City in October 2004.
Doyle will be assisted by south Wales duo Mark Dyson and Kim Fisher.
Photo: Sportsfile.