The five-times Welsh Premier Golden Boot winner was taken to hospital with a nose injury after last week's Welsh Cup win over Aberystwyth and manager Andy Legg will make a decision on his fitness today.
The Reds' chief will definitely be without suspended former Lincoln City wingman Owain Warlow, while midfielder Antonio Corbisiero and veteran Jason Bowen face late fitness tests.
But Legg is confident his side can shock the Saints: "We can go there and win, I'm convinced about that," he said.
"The artificial pitch is not ideal and we will have to adjust, but we will not moan about it and make it an excuse.
"We are getting back on track following the injury crisis and starting to play as I know we can, so we are going there at the right time."
Llanelli have a poor record at the Saints, having only won twice and drawn twice in 13 visits. Their last success was in 2006, when Griffiths and Spaniard Jacob Mingorance gave them a 2-0 victory.
TNS have been in stunning form at home with seven straight wins which have yielded 34 goals - an average of nearly five per game.
Photo: Rhys Griffiths is an injury doubt for Llanelli.